Posts Tagged ‘tumor growth’

Chemo-Brain is part of Cancer Progression and Chemotherapy

Friday, December 1st, 2017

Chemo brain or chemo fog are the memory and thinking problems experienced by cancer survivors are not just the result of chemotherapy but may start as the tumor forms and develops  before chemo was used according to a new study published in the journal Neuroscience.  Researchers found that female mice with a form of breast cancer demonstrat4ed impaired performance on learning and memory tests before chemotherapy drugs were used., They said “Our work isolated that the cancer is responsible for some of the memory and thinking complaints experienced by cancer survivors, and that drug therapy adds to the problem.” “Both factors independently effect brain function in different ways, which can lead to the development of other psychological disturbances, such as anxiety and depression.” Researchers said as many as 65on. taking longer to complete tasks, and difficulty multitasking.

Progression of tumor and later chemotherapy lead researchers to the identification of three different brain changes. 1)The combination of tumor growth and chemotherapy led to shrinkage of . While the tumor is developing, the body’s immune system releases cytokines  to inhibit the cancer development. Researchers found this reaction caused in the brains nervous system impairing its function. 2) Chemotherapy limited the production of new brain cells in the regions responsible for memory function which lead to a loss of memory. 3)  The combination of tumor growth and chemotherapy lead to shrinkage in brain regions that are important for learning and memory.

the study involved female mice, half with cancer and the other half without. Learning and memory tests were administered initially to determine the the impact of the tumor on the brain. After this mice were either given chemo or a saline solution (control). .Tests were again administered plus some additional ones. After testing was completed researchers brain images, tissue, and blood samples were used to analyze changes in brain structure and cytokinase activity mentioned earlier Before treatment mice with tumors performed less well on memory and learning tests than mice without tumors. After chemotherapy the performance of cancerous mice worsened, and the non-cancerous mice also showed sign’s of deterioration     Further research is planned..

 

Can Melatonin Influence Tumor Growth in Some Breast Cancers?

Friday, February 7th, 2014

logo1267406_mdA new study published online in the journal PLoS One concluded that preliminary results show that melatonin, a hormone that regulates our sleep and awake cycles, may have the potential to inhibit the growth and cell production nd block the formation of new blood vessels in
ER-negative breast cancer models. Researchers said “These early stage research results with the melatonin drug in a triple-negative breast cancer animal model achieved in our lab has not been seen anywhere else.”

To determine the effectiveness of of melatonin on tumor growth, researchers evaluated the action of melatonin on angiogenesis (f0rmation of new blood vessels)  in ER-negative breast cancer in vitro and in vitro using cells and mouse models respectively, Mice were randomly assigned to the study or control group and the  study group received treatment of melatonin one hour before lights were turned out  for 21 days. The time coincided with the time that cells are most sensitive to the hormone. . At the end of the 21 nights researchers used single photon emission computed tomography (SPECT) to determine whetehr the melatonin therapy effectively decreased the size of the implanted human triple negative breast cancer in the mouse model and if there was any change in the formation of new blood vessels. In addition, tumor volume was measured weekly and and tumor tissue was analyzed at the end of treatment.

None of the treated mice showed any loss of weight and lethargy during the treatment and most showed excessive movement with no aggressive or irritable behavior. After 21 days the treated mice showed significantly smaller tumors but the mean tumor volume increased significantly in the control group.These results were replicated in the cell model. The results indicate that melatonin may have the potential as a therapeutic agent for breast cancer. However, the researchers caution that the research is in a very early stage and results are not yet ready to be translated for patient use.

 

 

 

Low-Carb, Hi-Protein Diet May Reduce Cancer Risk and Tumor Growth

Wednesday, June 22nd, 2011

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A new study published in Cancer Research, a journal of the American Association for Cancer Research, and based upon mice research concluded that eating a diet high in protein and low in carbohydrate may reduce the risk of cancer and slow the growth of tumors.

The researchers implanted various strains of mice with human tumor cells or with mouse tumor cells and assigned them to one of two diets. One diet that was typical of Western diets contained about 55% carbohydrates, 23% protein and 22% fat. The other diet was high in protein, contained 15% carbohydrate , 58% protein, and 26% fat.

Findings showed that tumors consistently grew slower in the Hi-Protein, Lo-Carb diet. In one group of mice genetically predisposed to breast cancer half were placed on the Western type diet and half on the other diet. Almost half of those on the Western type diet developed breast cancer within the first year whereas none of those on the other type diet did. In addition, only one of the mice on the Western type diet reached age 2 (normal life span) and 70% of them died from cancer. Conversely over half of those on the Hi Protein, Lo-Carb diet live to age two and only 30% developed cancer.
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It is interesting that alternative physicians have utilized this information for years using an intervention that reduces carbohydrates as part of the insulin potentiation treatment. It is also interesting that 36 years ago when I was given 6 months to live when diagnosed with lung cancer and sought out an alternative physician , part of my alternative treatment was a diet that eliminated most carbohydrates and all simple sugars.