Posts Tagged ‘vitamin A’

Reduced Stem Cell/Vitamin A Deficiency

Wednesday, May 10th, 2017

Lack of a Vitamin A metabolite causes a loss of important stem cells according to new research published in Cell. This metabolite known as retinoic acid is essential in the process of activating and inactivating stem cells to regenerate cells. Specialized cells in the skin, gut, or blood have a short lifespan and require steady replenishment from adult stem cells that divide continuously. In 2008 it was discovered that a group of special stem cells in the bone marrow remain dormant most of the time and only become active to fight bacteria or viruses, durinmg heavy vlood loss, or as a result of chemotherapy. When their work is done these most potent stem cells return to dormancy. Current researchers found the mechanism that activate or deactive stem cells and that is the retinoic acid , a metabolite of vitamin A, that is crucial to the activation-deactivation process.

In the mice studies they found that stem cells are lost as a reservoir when they lack retinoic acid. Feeding the mice a diet deficient in vitamin A caused a loss of stem cells. This study added to those previously that showed vitamin A deficiencies impaired the immune system.

Can vitamin A assist in cancer prevention?

Wednesday, April 9th, 2014

logo1267406_mdResearch published recently in the International Journal of Oncology concluded that a derivative of vitamin A known as retinoic acid that is found in carrots and sweet potatoes helps pre-cancer cells revert back to normal cells. The researchers exposed four types of breast cells to different concernatrations of retinoic acid including normal, precancerous, cancerous, and fully aggressive cancer cells. They noted that precancer cells began to look like normal cells in shape but also changed their genetic signatyure back to normal. There were 443 genes in the precancer cells that were either up or down regulated on their way to becoming cancerous and that changed back to normal. The researcher said “we were able to see this effect of retinoic acid because we were looking at four distinct stages of breast cancer. However, the cells that were fully cancerous did not respond to the retinoic acid suggesting that there may be a small window of opportunity for the compound to help in preventing cancer progression. In addition, they found that only one concentration of the retinoic acid (about one micro Molar) produced the anti-cancer effect. They found that lower doses produced no change and higher doses produced a smaller effect. Further research is planned.

NB: IT IS INTERESTING TO ME THAT WHEN I HAD LUNG CANCER 39 YEARS AGO, MY DOCTOR PRESCRIBED HIGH DOSES OF VITAMIN A FOR THE PURPOSE OF PREVENTING NORMAL CELLS CONVERTING TO CANCER CELLS. THIS IS ONE OF THE LAST PRESCRIBED TREATMENTS IN MY REGIME TO BE VALIDATED BY RESEARCH. WHAT A PROGRESSIVE DOCTOR I HAD IN DR TOM ROBERTS FOR WHOM I WILL BE FOREVER GRATEFUL. GOD BLESS YOU DR ROBERTS FOR ALL YOU DID FOR ME AND OTHERS.