Posts Tagged ‘vitamin E’

Is Excessive Vitamin E Intake a Health Concern?

Wednesday, April 24th, 2013

logo1267406_mdA new study published in the Journal of Lipid Research concluded that biological mechanisms exist to routinely eliminate excessive levels of vitamin E in the body that make it almost impossible to take a harmful amount.  An expert from the linus Pauling Institute at Oregon State University says no level of vitamin E in the diet of from any normal us of supplementation should be a concern and another international expert said ” I believe that past studies which have alleged adverse consequences from vitamin E have misinterpreted the data.” Taking too much vitamin  E is not the real concern.” “A much more important issue is that more than 90% or people in the united /States have inadequate levels of vitamin E in their diets.”

In their review of how vitamin E is metabolized the researchers found that two major systems in the liver work to control the level of vitamin E in the body and routinely excrete excessive amounts. Very high levels of vitamin E supplements will double the tissue levels which are not harmful according to the article. The researcher said “Toxic levels of vitamin E in the body simply do not occur. Unlike some other fat soluble vitamins such as Vitamin A and D, it’s not possible for toxic levels of vitamin E to accumulate in the liver and other tissues.”

Vitamin E found in oils, meat and some other fo0ds  is often consumed in inadequate dietary levels and is an antioxidant needed for proper functioning of many organs, nerves, and muscles. and can reduce blood clotting.  Other roles include protecting polyunsaturated fatty acids from oxidizing,  may help protect other essential lipids, and may have value in many degenerative diseases.

(It is of interest that I used high doses of vitamin E as part of my treatment regime for lung cancer 38 years ago to help reduce the toxic effects of therapeutic does of vitamin A and was a concern to me at the time because both were fat soluble vitamins.)

 

Can a High Dietary Antioxidant Intake Cut the Risk of Pancreatic Cancer?

Wednesday, August 1st, 2012

New research published in the journal Gut concluded that increasing the dietary intake of the antioxidant vitamin C, E. and selenium can help reduce the risk of pancreatic cancer by up to two-thirds and if the relationship turns out to be causal one in twelve of these cancers might be prevented.

Researchers tracked the health of over 23,500 people between age 40 and 74 between 1993 and 1997.  All participants completed a comprehensive food diary over 7 days detailing the type and amount of all food they ate and the methods they used for preparing it. Each entry in the food diary was matched to one of 11,000 food items and the nutrient values calculated using a special computer program.  Within 10 years of entering the study forty-nine people (55% men) developed pancreatic cancer and by 2010 this number increased to 86 (45% men). On average pancreatic participants survived 6 months after diagnosis.

The nutrient intake of those who were diagnosed with pancreatic cancer within 10 years of entering the study were compared with the nutrient intake of almost 4,000 health people. Analysis showed that a weekly intake of selenium in the top 25% of consumption had almost 1/2 the risk of developing pancreatic cancer compared with those whose intake was in the bottom 25%. And those wit a vitamin C, E. and selenium in the top 25% of consumption were 67% less likely to develop pancreatic cancer than those in the bottom 25% of intake.  The researchers say that if this relationship turns out to be causal that would mean preventing more than one in twelve (8%) cases of pancreatic cancer.

Can Vitamin E Reduce Liver Cancer Risk?

Friday, July 27th, 2012

A new study published in the Journal of the National Cancer Institute concluded that high consumption of vitamin E  from diet or supplements may lower the risk of liver cancer. Although we rarely hear about liver cancer, it is the third most common cause of cancer mortality in the world and a large percentage of these occurs in developing countries.

Data was analyzed from 132,737 people in China who were enrolled in the Shanghai Women’s Health Study from 1997 to 2000, or the Shanghai Men’s Health Study from 2002 to 2006.

In-person interviews to gather data on dietary habits were conducted using validated food-frequency questionaires.  Questions were included on how often participants ate some of the most commonly consumed Shanghai foods and whether or not they took vitamin supplements. Liver cancer risk was then determined between those with high and low vitamin E intake.

There were 267 liver cancer patients (118 women and 149 men) diagnosed between 2 years after study enrollment and an average of 10.9 years for women and 5.5 years for men. Researchers found that vitamin E intake from both food and supplements were associated with a lower risk of liver cancer. The researchers said ” We found a clear, inverse dose-response relationship between vitamin E intake and liver cancer risk.” “Overall, the take home message is that the high intake of vitamin E either from diet or supplements was related to lower risk of liver cancer in middle -aged or older people from China.”  Conversely, those who had the highest intake of vitamin C intake from supplements who had a family history of liver disease or self-reported liver disease were more likely to develop liver cancer.

Daily Pistachios May Reduce the Risk of Lung Cancer

Friday, March 11th, 2011

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A study recently presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference concluded that a diet that includes daily pistachios may help reduce the risk of lung cancer. Pistachios are a known source of of gamma-tocopherol so eating them increases the intake of gamma-tocophenoli, a form of vitamin E, and from research it has been suggested that vitamin E is protective against prostate cancer. The researchers,thus, thought it might also help prevent lung cancer.

In the study 36 healthy participants were randomly assigned to an intervention or control group with 18 in each. The methodology included a 2 week baseline period followed by a 4 week intervention period. During the intervention period the subjects were given 68 grams (about 2 ounces or 117 kernels) of pistachios daily while the control group continued with their normal diet only.

The effect of the intake on serum cholesterol-adjusted gamma-tocopherol was investigated using the Nutrition Data system for Research Version 2007 for intake and consumption was measured by monitoring the diet diaries and measuring the weight of returned pistachios. The researchers found a significant increase in energy-adjusted dietary intake of gamma-tocopherol during the third and fourth weeks for those who included the pistachios in their diet. Similar results were found at week five and six compared to those in the control group. The cholesterol-adjusted serum gamma-tocopherol was also significantly higher in the pistachio group at the end of the study period compared to their baseline data. Further research is needed to validated the potential relationship between gamma-tocopherol levels and lung cancer risk.

More information is available at:
http://webcache.googleusercontent.com/search?q=cache:0weeYSLz4JEJ:www.aacr.org/home/public–media/.

Prostate Cancer and Vitamin E

Friday, October 29th, 2010

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Researchers at Queensland University of Technology report that the survival rate of those+ with prostate cancer may increase in the future due to a new vitamin E treatment. Because existing chemotherapy and hormone therapy treatments for prostate cancer do not kill the prostate cancer stem cells believed to cause the regrowth of prostate cancer, the researchers discovered a specific form of T3, called gamma tocotrienol (y-T3) that successfully kills prostate cancer stem cells and has the potential to inhibit the recurrence of prostate cancer. Using mice implanted with the prostate cancer cells and fed vitamin E in a 1 year study over 70% showed no cancer formations. In the remaining subjects of the experimental group tumor regrowth was considerably reduced and in the control group 100% of the subjects had tumor regrowth. Further information is available at: Queensland University of Technology (2010, October 24) Vitamin E in front line of prostate cancer fight. Science Daily Retreived October 24, 2010 from
http://www.scoencedaily.com/releases/2010/101019111718.htm