Posts Tagged ‘death’

Can Curcumin and Silymarin Inhibit Colon Cancer Cell Spread and Growth.

Wednesday, July 27th, 2016

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A new study published in the Journal of Cancer concluded that a preliminary study finds curcumin, an active ingredient in spicy curry dishes, and silymarin, a compound of milk thistle, inhibited the spread of colon cancer cells and increased cancer cell death. Researchers studied a  line of colon cancer cells in a laboratory model and found that treating the cells initially with curcumin, and then with silymarin was more effective in killing/inhibiting spread  of cancer cells than treating cancer cells with either photochemical alone. They said “The combination of photochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death.”  They continued “Phytochemicals may offer alternate therapeutic approaches to cancer treatments and avoid toxicity problems and side effects that chemotherapy can cause.”

However, researchers reiter4ated that the results are preliminary lab results and more research is needed. Researchers need tos tudy how the curcumin and silymarin impact the actions of molecules, such as genetic transcription and expression, that cause cells to change. Thereafter, the chemicals would be studied in animal models and then in humans. They say also that concentrations of curcumin and silymarin that are too high might harm people so there is more to olearn. For now, they recommend sprinkling a little spice to food.

Can Smoking Interfere with Breast Cancer Treatment?

Friday, June 24th, 2016

 

Logos 005New research published in the British Journal of Cancer  concluded that common treatment for breast cancer works less well in patients who smoke, compared to non-smokers. The study followed 1,016 breast cancer patients in southern Sweden diagnosed between 2002 and 2012. At the time of surgery they were asked whether they were smokers or non-smokers and about one in five said they were a regular smoker or social smoker. The impact of smoking was evaluated based upon type of breast cancer treatment received after surgery.

Results showed that women over age 50 treated with aromatase inhibitors, were affected by smoking. The aromatase treatment prevents the body from generating estrogen in fatty tissue and thereby reduces the risk of recurrence in women with estrogen-receptive positive breast cancer. This treatment worked significantly better in non-smokers. Researchers said “Smokers who were treated with aromatase inhibitors had a three times higher risk of recurrence of breast cancer compared with the non-smokers who got the same treatment.” They also found that “the smokers also had an increased risk of dying, either from the breast cancer or from other illnesses, during the time we followed them.”

However, the researchers found little or no difference between smokers and non-smokers treated with the drug tamoxifen, radiotherapy, or chemotherapy. Despite telling patients of the importance of stopping smoking only ten perce of the 206 smokers stopped in the first year after surgery. Researchers said the number of smokers who stopper was too small to determine if that made a difference in their future risk. More research is needed.

Does Fitness Level Influence Risk of Cancer and Death in Men?

Wednesday, April 1st, 2015

Does Fitness Level Influence Risk of Cancer and Death in Men

A new study published in the online JAMA Oncology concluded that men with a high fitness level in midlife seem to be at lower risk for lung and colorectal cancer, but not prostate cancer. In addition, a higher fitness level may also predict aa lower risk of death if they are diagnosed with cancer when they are older.

The purpose of the study was to look at the association between midlife cardiorespiratory fitness (CRF) and the incidence of cancer and survival at age 65 or older. The study included 13,949 men who had a baseline fitness exam where CRF was measured in a treadmill test between 1971 and 2009. Lung cancer, prostate and colorectal cancers were assessed on this group using medicare data between 1999 and 2009. during an average surveillance period of 6.5 years for the men, 1310 developed prostate cancer, 200 lung cancer, and 181 developed colorectal cancer.  Results showed that high CRF in midlife was associated with a 55 percent lower risk of lung cancer, and a 44 percent lower risk of colorectal cancer compared to men with low CRF. However, this association was not seen between high CRF and lower prostate cancer risk. Researchers also found that high CRF in midlife was associated with a 32 percent lower risk of cancer death among men who developed lung, colorectal or prostate cancer at age 65 compared with men who had alow CRF.  In addition, high CRF in midlife was associated with a 68 percent reduction in cardiovascular disease death (CVD) compared with low CRF among men who developed cancer.  Further research is needed to determine specific levels of CRF necessary toi prevent site specific cancer.

Can Television Watching Time Influence Death Among Breast Cancer Survivors.

Friday, February 8th, 2013

logo1267406_mdA study published in Springer ‘s Journal of Cancer Survivorship concluded that spending a lot of time watching television after a breast cancer diagnosis is not linked to death in breast cancer survivors. After accounting for physical activity levels, this sedentary practice was not an independent risk factor for death.  Past research has shown that physical activity after a breast cancer diagnosis may reduce the risk of death and sedentary time may have a negative effect on this population but this was one of the first to look at sedentary life and death.

In the study 687 women with breast cancer who had been diagnosed 2 1/2 years earlier were asked about the amount of time they spent sitting and watching television  and the type, duration, and frequency of activities they performed in the past year. The group was followed for 7 years during which time 89 died.  overall, women who watched most television were older, more overweight and less active than those who watched the least. More deaths were observed in those who watched the most television but once seal-reported physical activity levels were accounted for along with other important risk factors, the relationship between watching more television and death no longer  significant.

Researchers said “It is possible that there is no true independent relationship between post-diagnosis television time and death. HEAL survivors who reported the most television time also reported the equivalent of  140 minutes per week of moderate -to-vigorous intensity physical activity–which is the amount recommended to all adults for general health.  Perhaps with this amount of recreational activity, television time may not have an independent effect on survival.”

Breast Cancer Women Increase Risk of Death by Smoking

Friday, November 19th, 2010

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Research presented at the Ninth Annual American Association of Cancer Research Frontiers in Cancer Prevention Research Conference concluded that “women who are current smokers or have a history of smoking had a 39 percent higher rate of dying from breast cancer…..even after accounting for a wide array known prognostic factors including clinical, socioeconomic and behavioral factors.”

Two thousand two hundred sixty seven multi-ethnic women diagnosed with breast cancer between 1997 and 2000 were enrolled into the study and followed for an average of 9 years. Causes of deaths in the group were examined for deaths of smokers that were related to breast cancer, non breast cancer, and all causes. There were 164 breast cancer deaths and 120 non-breast cancer deaths at follow up. Of the deaths those who were current smokers or had a history of smoking had a 39% increased rate of dying from breast cancer and a twofold increased risk of dying from non-breast cancer causes than those who never smoked. Additional information can be found at:

http://www.sciencedaily.com/releases/2010/11/101108190130.htm

PSA Blood Test May Accurately Predict Prostate Cancer Deaths

Friday, September 24th, 2010

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A new study published in the British Medical Journal online concluded that a blood test at age 60 could accurately predict the risk of death from prostate cancer within the next 25 years.
In the study researchers analyzed the blood samples of 1,167 men born in 1921. Blood samples were collected in 1981 and 1982 and all subjects were followed until age 85 or death. Following a review of biomarkers the researchers found that the PSA was a highly accurate predictor of long term risk of prostate cancer death.

One hundred twenty six men were diagnosed with prostate cancer and in that group 90% of the deaths occurred in those who were in the top 25% of the PSA levels at age 60. The researchers concluded that those with a PSA above 2ng/ml at age 60 should be considered at high risk of aggressive prostate cancer and should continued to be followed. Those with a PSA under 1ng/ml at age 60 had a 0.2 percent chance of prostate cancer death and should be considered at low risk of prostate cancer death and even when prostate cancer is present it is not likely to cause symptoms or shorten their life up to age 85.

Risk of Aggressive Prostate Cancer linked to Common Sexual Infection

Wednesday, September 30th, 2009

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A new study from the Harvard School of Public Health and Brigham and Women’s Hospital reported on the September 9, 2009 Journal of the National Cancer Institute website reported a strong association between Trichomonas vaginalis, a common sexually transmitted infection, and the risk of advanced and lethal prostate cancer in men.
An important risk factor for prostate cancer is inflammation but the source has been unclear. Trichomonas vaginalis can infect the prostate and may be the source of inflammation.

A previous study found an association between Trichomonas Vaginalis infection and prostate cancer but was too small to determine if there was a link between the infection and advanced and lethal prostate disease. In the current stuidy researchers analyzed the blood samples from 673 men with prostate cancer and compared infection status based upon antibody levels with 673 control subjects who were not diagnosed with prostate cancer. The samples of blood were collected in 1982, on an average a decade before the cancer diagnoses.
Results showed that Trichomonas vaginalis infection was associated with over a two fold increase risk of prostate cancer that was at an advanced stage at diagnoses and a nearly three-fold increase in prostate cancer that would result in death. Further research is needed.