Posts Tagged ‘DNA’

Meditation/Yoga Reverse DNA Response Underlying Stress

Wednesday, June 21st, 2017

 

A new study published in the journal Frontiers in Immunology reviewed over a decade of studies  analyzing how our genes are affected by different Mind-Body Interventions and and concluded meditation, yoga and Tai Chi don’t simply relax us, they can reverse the molecular reactions in our DNA which cause ill-health and depression. Researchers reviewed 18 studies with 846 participants over 11 years and found a pattern of molecular changes that happened in the body as a result of the mind-body interventions.  Those changes benefited the mental and physical health of the participants.

When a person is exposed to a stressful situation, their sympathetic nervous system is triggered  that in turn increases production of af a molecule called nuclear factor kappa B (NF-kB) that regulates how the genes are expressed. KF-kB translates stress by activating genes to produce protein called cytokines that cause inflammation at the cellular level-a reaction that is useful for short term fight or flight reactions. But if this persists it lead to a higher risk of cancer. accelerated aging, and psychiatric disorders like depression.  Researchers found, however, that people who practice mind-body interventions exhibit the opposite effect-that is, a decrease in production of NF-kB and cytolines, leading to a reversal of the pro-inflammatory gene expression pattern and a reduction in the risk of inflammation-related diseases and conditions.

Researchers said “These activities are leaving what we call a molecular signature in our cells, which reverse the effect that stress or anxiety would have on the body by changing how our genes are expressed. Put simply, MBIs cause the brain to steer our DNA processes along a path which improves our well-being.” “More needs to be done to understand these effects in greater depth, for example how they compare with other healthy interventions like exercise or nutrition. But this is an important foundation to build on to help future researchers explain the benefits of increasingly popular mind-body activities.”

Can Gene Inactivation Prevent Aging and Cancer?

Wednesday, March 8th, 2017

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A new study published in the journal Nature concluded that every body cell contains the complete DNA library and the so called methyl groups regulate the DNA library in tissues so that only the genetic information needed in that tissue is expressed. Now for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, subsequently may lead to the emergence of cancer.

Each body cell contains the entire building plan of the whole organism written in the DNA and comprises single genes that determine the specific attributes of the individual.  Gene expression builds tissue cells with tissue-specific attributes. Thus, genes information is activated that forms cells identified as intestinal cells or lung cells etc. In this regulated process methyl groups play an important role. If they are enzymatically bound to a gene’s starting point, known as the promoter, the respective gene is inactivated and the DNA is methylated. As we age and develop age-related diseases such as cancer the activation of genetic information is increasingly defective. However, until now, the detailed processes of these errors and the role of  DNA methylation  in these processes has been poorly understood.

Researchers have known for some time that DNA methylation at the promoter of a gene functions as an on/off switch. However, it was unknown in epigenetics why DNA within the gene body housing the important genetic information is methylated also which was answered in this research. This research showed that genes also aberrant activated if–beyond promoters–DNA methylation is missing within the gene body. Subsequently aberrant proteins are produced that impinge on the cell structure that result in massive disruption of the function and identity of a cell and cell degradation occurs and cancer may emerge.  Researchers concluded “this new knowledge that a lack of DNA methylation at the gene body  may lead to the production of aberrant proteins, might offer a target for cancer therapy. If we succeed to find a way to traffic methyl groups to non-methylated DNA sequences of cancer cells, we could possibly stop proliferation of these cells.”

Can High Risk Breast Cancer Recurrence Patients be Identified?

Friday, September 25th, 2015

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A new study published in the journal Clinical Epigenetics concluded that a new simple blood test might be able to determine the risk of recurrence, or the cancer invading other organs such as the lungs, bone or brain for women successfully treated for breast cancer. Researchers identified 21 DNA hypermethylation hotspots–gene locations along the 3 billion chemical bases of DNA–with increased levels of methylation that could indicate the existence of metastatic cancer.  They said “These findings could lead to a highly sensitive blood-based test panel–a type of liquid biopsy–which could help improve the care of women with breast cancer.” They said further “This 21-gene signature is a potential biomarker that could indicate patients who are at high risk of cancer recurrence, either in the breast or elsewhere in the body, and who might benefit from additional therapy to eliminate the potential of recurrence.” In this study the 21 genes that were differentially methylated were consistently higher in patients with metastatic breast cancer when compared with levels in healthy individuals and cancer free survivors.

 

Can a Blood Test Detect All Types of Cancer?

Wednesday, August 6th, 2014

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New research published online in FASEB Journal, The U.S.Journal of American Societies for Experimental Biology, concluded that a revolutionary blood test that could detect any type off cancer was developed by British scientists. The test6 has been shown to diagnose cancer and pre-cancerous conditions from blood of patients with melanoma, colon cancer and lung cancer with a high degree of accuracy. Researchers assessed white blood cells and measured the damage caused to their DNA when subjected to different intensities of ultraviolet light that is known to damage DNA. They found a clear distinction between the damage to the white blood cells from patients with cancer, with precancerous conditions, and from healthy patients. They also found that  people with cancer have DNA that is more easily damaged by untraviolet light than other people.

Results were based upon blood samples of 206 people of which 94 were healthy and 114 were patients  in specialist clinics prior to diagnosis and treatment. Ultra violet damage was observed in the form of pieces of DNA being pulled in an electric field toward the positive end of the field, causing a comet like tail. The longer the tail the more the DNA damage and this correlated with patients who were ultimately diagnosed with cancer(58) and precancerous conditions (58) and those who were healthy (94). Further clinical research is evaluating the tests accuracy.

Improve Your future with Information From JZ Knight Interview.

Sunday, March 4th, 2012

J Z Knight was interviewed yesterday by Dr Carl O Helvie, Host, the Holistic Health Show.  J Z Knight is  the renowned channel and star of the acclaimed film What the Bleep Do We Know? She is the channel for Ramtha and founder of the Ramtha School of Enlightenment. More information was presented earlier on this blog and can be found at: http://www.ramtha.com and http://www.JZKnight.com Listen to the interview below.